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Results: Transient increases 3 to 31-fold from baseline in immune biomarkers associated with immune activation (sCD40, sCD28, sCD80, sCD86), Th1 cell-mediated response (IL-6, IL-12 p40, IL-12 p70, IL-7, IL-10), inflammation regulation (GROa, PDGF-AA, PDGF-AB, VEGF), and immune checkpoint proteins (PD-1, PD-L1, CTLA-4, LAG-3, BTLA) were observed during IDR lead-in, with peaks occurring during the plateau of HBsAg reduction in assessed subjects to date

The rationale is that many nutraceuticals could work in synergy: by delivering them simultaneously at the right ratio, one might amplify health benefits or address multiple targets in the body

These findings suggest that METH may influence cell function and neuronal health by regulating autophagy processes